Omega 3, Depression & Bipolar (2007)

This study investigated omega 3, depression and bipolar. A meta-analysis (review of studies to date) by scientists in Taiwan suggests that omega-3 fatty acids have significant antidepressant effects in patients with depression and bipolar disorder. The researchers interpret the results cautiously, however, and recommend large-scale, well-controlled trials are conducted to determine who would benefit most from fish oils, what level of dose is required and specific composition of fish oils that should be used .

Lin PY and Su KP. ‘A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids’  J Clin Psychiatry, 2007 Jul;68(7):1056-61

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Omega 3 & Bipolar (2006)

This paper investigated omega 3 & bipolar. In a 12-week, double-blind study individuals with bipolar depression received either 1 g of EPA a day, 2 g/day or placebo, alongside their existing medication. Effectiveness of this treatment was assessed using the Hamilton Rating Scale for Depression (HRSD), as well as the Young Mania Rating Scale and Clinical Global Impression Scale (CGI). Significant improvement was seen with the EPA compared with placebo in the HRSD (P=0.04) and the CGI (P=0.004) scores. There was no apparent benefit of 2 g over 1 g dose. Both doses were well tolerated.

S Frangou et al., ‘Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study’, Br J Psychiatry, 188:46-50, 2006

Click here for the abstract

 

Further info